Q- What is Teicoplanin?

Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria and a few bacterias which are resistant to antibiotics, for example, methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. 

Q- What is the mechanism of action of Teicoplanin?

Teicoplanin mechanism of action is to inhibit bacteria's cell wall synthesis.

Q- Is Teicoplanin better than Vancomycin?

Teicoplanin antibiotic activity is similar to Vancomycin antibiotics. But there are lower incidences of adverse events with Teicoplanin over Vancomycin. Unlike Vancomycin, routine drug monitoring is not required. Teicoplanin is more effectively administered once daily than Vancomycin and it can be given intramuscularly or intravenously. 

Q- What precautions to be taken while using Teicoplanin?

According to a few studies

  • Hypersensitivity, fever, rash, affects kidney and ear function, fever, low blood pressure, diarrhea, and low platelet count occurred in very few patients.
  • Local reactions at the injection site include pain, redness, or discomfort after intramuscular injection, or inflammation of the vein after intravenous injection. 
  • Allergic reactions and skin reactions have occurred during the infusion of Teicoplanin with fever and low blood pressure.
  • The red man syndrome associated with rapid infusion of Vancomycin, resulting in histamine release, is very rarely seen with Teicoplanin. 
  • Teicoplanin can usually be safely administered to patients with a history of red man syndrome due to Vancomycin, as has been confirmed in six children treated with Teicoplanin for febrile neutropenia and Gram-positive bacteremia.

Q- What are the common side effects of Teicoplanin?

 Hypersensitivity response (fever, rash, chills, or itching). Increased bleeding tendency is seen with reaction to   Acenocoumarol, Dicoumarol, Fluindione, Phenindione, Phenprocoumon, Warfarin, Typhoid vaccine, Vibrio cholera CVD 103-HgR strain live antigen. 

Reference- https://www.sciencedirect.com/science/article/pii/B9780444537171015079