Very-low-density lipoprotein (VLDL) is another type of cholesterol that is especially harmful because it is made up of even more triglycerides, a type of fat, than LDL (“bad” cholesterol). Fibrates reduce the liver’s production of VLDL and speed up the removal of triglycerides from the blood. They are modestly effective in increasing HDL but are not effective in lowering LDL. Fibrate drugs are Lopid (gemfibrozil) and Tricor (fenofibrate).